Gu Yan reagent-scientists mix blood of young and old mice to create elixir

An interesting animal experiment led scientists to the idea of ​​making "elixir". They mixed the blood of old and young mice, which is expected to rejuvenate elderly patients in the future.

A research team led by Amy Weggers of the Harvard Stem Cell Society in the United States found that the blood of young mice can make the bone marrow blood stem cells of old mice become young and rejuvenated, and can also restore the ecology of nourishing, supporting and stimulating blood stem cells and bone marrow. The young state of the cell. Although old mice have more blood stem cells and ecological cells than young mice, the activity of these cells is poor, and although they are in large numbers, they cannot achieve the function of repairing the body like young mice. Amy said: "This method may encourage old animals to return to a young state, thereby making up for the defects of cells in old animals. Old mice have bone marrow blood cells that can induce inflammation and develop cancer, while having less lymphoid Cells can play a role in tissue repair. "

When Amy extracted cells from a 21-month-old mouse and injected it into a 2-month-old mouse, all the state of vitality recovery was subverted-fewer bone marrow cells and more lymphoid cells were formed in the mouse. Based on a longer-term experiment, Amy speculated that these blood components were loaded with a hormone called insulin-like growth factor 1 (IGF-1) through the module, which may repair damaged cells in the aged mouse, insulin-like growth factor 1 Related to the aging process, it can accelerate the aging of mouse ecological cells. As expected by the research team, when the researchers injected antibodies that counteract IGF-1 into the aged mice, the ecological cells and stem cells could remain young.

Amy pointed out that the injection of antibodies that counteract IGF-1 in the bone marrow of elderly patients is not absolutely safe and effective. This is because IGF-1 plays an important role in the growth of human muscles and bones, and injecting IGF-1 into the human body will have some side effects. The research team is currently looking for a way to prevent the exchange of chemical signals of IGF-1 products, especially the IGF-1 factor in the bone marrow. She emphasized that this method is not a one-time effect, but requires long-term continuous treatment to be effective.

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